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Evidence-based Guideline: Antiepileptic Drug Selection for People with HIV/AIDS Neurol 78:139-145, Birbeck,G.L.,et al, 2012 See this aricle in Pubmed Article Abstract It may be important to avoid enzyme-inducing AEDs in people on ARV regimens that include protease inhibitors or nonnucleoside reverse transcriptase inhibitors, as pharmacokinetic interactions may result in virologic failure, which has clinical implications for disease progression and development of ARV resistance. If such regimens are required for seizure control, patients may be monitored through pharmacokinetic assessments to ensure efficacy of the ARV regimen (Level C).

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